In vitro nifedipine release from poly(lactic acid)/chitosan nanoparticlesloaded with nifedipine

Nguyen Thuy Chinh, Nguyen Thi Thu Trang, Nguyen Vu Giang, Dinh Thi Mai Thanh, To Thi Xuan Hang, Nguyen Quang Tung, Chu Quang Truyen, Pham Minh Quan, Pham Quoc Long, Thai Hoang.

Bài báo của nhóm tác giả thuộc: Viện Kỹ thuật nhiệt đới; Trường Đại học Công nghiệp Hà Nội; Viện Hóa học các hợp chất thiện nhiên. Bài báo được đăng trên tạp chí Applied Polymer Science (2016).

DOI: 10.1002/app.43330

ABSTRACT: In this study, nanoparticles based on poly(lactic acid) (PLA), chitosan (CS), and nifedipine (NIF) were prepared by anemulsion method with poly(ethylene oxide) (PEO) as an emulsifier. We investigated the most suitable conditions for preparing thepoly(lactic acid)/chitosan/nifedipine nanoparticles (PCNs) by changing the distilled water volume, PEO content, and PLA/CS ratio.NIFs with different contents were loaded into poly(lactic acid)/chitosan nanoparticles (PCs) to study in vitro drug-delivery systems.The PCNs were characterized with a Zetasizer particle size analyzer, field emission scanning electron microscopy, Fourier transforminfrared (FTIR) spectroscopy, and X-ray diffraction (XRD) methods. From the obtained results of the particle size parameters of thePCNs, the most suitable conditions for the preparation of the PCNs were found. The FTIR spectroscopy and XRD results show thatNIF was loaded into the PCs. The PCNs had major basic particle sizes in the range 20–40 nm. NIF release from the PCNs was studiedas a function of the pH of the immersed solution, the immersion time, and the NIF content. The kinetics of drug release were investigated and are reported to determine the type of release mechanism. V C 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43330.

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